GPX4

glutathione peroxidase 4

Details

HGNC: HGNC:4556
GeneCards: GPX4
NCBI: 2879
Ensembl: ENSG00000167468
UniProt: P36969
OMIM: 138322
UCSC: uc021umg.3
VEGA: OTTHUMG00000181874
ENA: BC039849, X71973
Alias Symbols: PHGPx, MCSP
Previous Symbols: None
Alias Names: "phospholipid hydroperoxidase", "selenoprotein GPX4"
Previous Names: "glutathione peroxidase 4 (phospholipid hydroperoxidase)"

Associated Studies

Oxidative stress is a shared characteristic of ME/CFS and Long COVID

2025 | Shankar, Vishnu; Wilhelmy, Julie; Curtis, Ellis J.; Michael, Basil; Cervantes, Layla; Mallajosyula, Vamsee A.; Davis, Ronald W.; Snyder, Michael; Younis, Shady; Robinson, William H.; Shankar, Sadasivan; Mischel, Paul S.; Bonilla, Hector; Davis, Mark M.

Associated cohorts
Phenotype: Long COVID, Long COVID - CDC 2022 criteria
Phenotype: ME/CFS, ME/CFS - CCC criteria, ME/CFS - Fukuda criteria, ME/CFS - IOM (Institute of Medicine) 2015 criteria, Post-exertional malaise (PEM)

Transcriptional reprogramming primes CD8+ T cells toward exhaustion in Myalgic encephalomyelitis/chronic fatigue syndrome

2024 | Iu, David S.; Maya, Jessica; Vu, Luyen T.; Fogarty, Elizabeth A.; McNairn, Adrian J.; Ahmed, Faraz; Franconi, Carl J.; Munn, Paul R.; Grenier, Jennifer K.; Hanson, Maureen R.; Grimson, Andrew

Associated cohorts
Phenotype: ME/CFS, ME/CFS - CCC criteria, ME/CFS - IOM (Institute of Medicine) 2015 criteria, Post-exertional malaise (PEM)