TLR4

toll like receptor 4

Details

HGNC: HGNC:11850
GeneCards: TLR4
NCBI: 7099
Ensembl: ENSG00000136869
UniProt: O00206
OMIM: 603030
UCSC: uc004bjz.5
VEGA: OTTHUMG00000021046
ENA: U88880
Alias Symbols: hToll, CD284, TLR-4, ARMD10
Previous Symbols: None
Alias Names: None
Previous Names: "toll-like receptor 4"

Associated Studies

Upregulation of olfactory receptors and neuronal-associated genes highlights complex immune and neuronal dysregulation in Long COVID patients

2025 | Shahbaz, Shima; Rezaeifar, Maryam; Syed, Hussein; Redmond, Desiree; Terveart, Jan Willem Cohen; Osman, Mohammed; Elahi, Shokrollah

Associated cohorts
Phenotype: Long COVID, ME/CFS, ME/CFS - CCC criteria, Post-exertional malaise (PEM)

HERV activation segregates ME/CFS from fibromyalgia while defining a novel nosologic entity

2025 | Giménez-Orenga, Karen; Martín-Martínez, Eva; Nathanson, Lubov; Oltra, Elisa

Associated cohorts
Phenotype: ME/CFS, ME/CFS - CCC criteria, ME/CFS - ICC Criteria, Post-exertional malaise (PEM)
Phenotype: Fibromyalgia, Fibromyalgia - 1990 ACR (American College of Rheumatology) criteria, Fibromyalgia - 2011 ACR (American College of Rheumatology) criteria

Single-cell transcriptomics of the immune system in ME/CFS at baseline and following symptom provocation

2024 | Vu, Luyen Tien; Ahmed, Faraz; Zhu, Hongya; Iu, David Shing Huk; Fogarty, Elizabeth A.; Kwak, Yeonui; Chen, Weizhong; Franconi, Carl J.; Munn, Paul R.; Tate, Ann E.; Levine, Susan M.; Stevens, Jared; Mao, Xiangling; Shungu, Dikoma C.; Moore, Geoffrey E.; Keller, Betsy A.; Hanson, Maureen R.; Grenier, Jennifer K.; Grimson, Andrew

Associated cohorts
Phenotype: ME/CFS, ME/CFS - CCC criteria, Post-exertional malaise (PEM)

Exercise-induced changes in gene expression do not mediate post exertional malaise in Gulf War illness

2023 | Boruch, Alexander E.; Lindheimer, Jacob B.; Ninneman, Jacob V.; Wylie, Glenn R.; Alexander, Thomas; Klein-Adams, Jacquelyn C.; Stegner, Aaron J.; Gretzon, Nicholas P.; Samy, Bishoy; Falvo, Michael J.; Cook, Dane B.

Associated cohorts
Phenotype: Gulf war illness - Kansas Case Definition Criteria, Gulf War syndrome