TNF

tumor necrosis factor

Associated Studies

Integrated immune, hormonal, and transcriptomic profiling reveals sex-specific dysregulation in long COVID patients with ME/CFS

2025 | Shahbaz et al.

Phenotype: Long COVID, ME/CFS, ME/CFS - Canadian Consensus Criteria (CCC) 2003, Post-exertional malaise (PEM)
Heightened innate immunity may trigger chronic inflammation, fatigue and post-exertional malaise in ME/CFS

2025 | Che et al.

Phenotype: ME/CFS
Abnormal T-Cell Activation And Cytotoxic T-Cell Frequency Discriminates Symptom Severity In Myalgic Encephalomyelitis/Chronic Fatigue Syndrome

2025 | Lee et al.

Phenotype: ME/CFS
Circulating miRNAs Expression in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome

2023 | Soffritti et al.

Phenotype: ME/CFS, ME/CFS - Fukuda 1994 (CDC) Criteria
MCP-1 is increased in patients with CFS and FM, whilst several other immune markers are significantly lower than healthy controls

2020 | Groven et al.

Phenotype: ME/CFS, ME/CFS - Fukuda 1994 (CDC) Criteria
Human Herpesvirus-6 Reactivation, Mitochondrial Fragmentation, and the Coordination of Antiviral and Metabolic Phenotypes in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome

2020 | Schreiner et al.

Phenotype: ME/CFS
Gene Expression Factor Analysis to Differentiate Pathways Linked to Fibromyalgia, Chronic Fatigue Syndrome, and Depression in a Diverse Patient Sample

2015 | Iacob et al.

Phenotype: ME/CFS, ME/CFS - Fukuda 1994 (CDC) Criteria
Immunological abnormalities as potential biomarkers in Chronic Fatigue Syndrome/Myalgic Encephalomyelitis

2011 | Brenu et al.

Phenotype: ME/CFS, ME/CFS - Fukuda 1994 (CDC) Criteria
A first study of cytokine genomic polymorphisms in CFS: Positive association of TNF-857 and IFNgamma 874 rare alleles

2006 | Carlo-Stella et al.

Phenotype: ME/CFS, ME/CFS - Fukuda 1994 (CDC) Criteria

Details

HGNC: 11892
GeneCards: TNF
NCBI: 7124
Ensembl: ENSG00000232810
UniProt: P01375
OMIM: 191160
UCSC: uc011fee.4
VEGA: OTTHUMG00000031194
ENA: X02910
Alias Symbols: TNFSF2, DIF, TNF-alpha
Previous Symbols: TNFA
Alias Names: "TNF superfamily, member 2"
Previous Names: "tumor necrosis factor (TNF superfamily, member 2)"