Oxidative stress is a shared characteristic of ME/CFS and Long COVID

Authors: Shankar, Vishnu; Wilhelmy, Julie; Curtis, Ellis J.; Michael, Basil; Cervantes, Layla; Mallajosyula, Vamsee A.; Davis, Ronald W.; Snyder, Michael; Younis, Shady; Robinson, William H.; Shankar, Sadasivan; Mischel, Paul S.; Bonilla, Hector; Davis, Mark M.

8 Jul 2025

View article | Discussion on S4ME

Cohorts in this study

Phenotype: Long COVID, Long COVID - CDC 2022 criteria

GPX4, IL2, PLA2G6, SOD2

Phenotype: ME/CFS, ME/CFS - CCC criteria, ME/CFS - Fukuda criteria, ME/CFS - IOM (Institute of Medicine) 2015 criteria, Post-exertional malaise (PEM)

GPX4, PLA2G4A, SOD2

Notes

Long COVID
- SOD2: Fig 3B
- GPX4 - Fig 4E
- IL2 - Section "Elevated Oxidative Stress in Memory CD4T and Altered T Cell Proliferation Responses to ROS in ME/CFS Donors Suggests a Deficient Adaptive Immune Response, upon Stimulation."
- PLA2G6 - Fig 5D

ME/CFS
- SOD2: Fig 3B
- PLA2G4A - Fig 4C
- GPX4 - Fig 4E