Multifaceted evolution focused on maximal exploitation of domain knowledge for the consensus inference of Gene Regulatory Networks

Authors: Segura-Ortiz, Adrián; Giménez-Orenga, Karen; García-Nieto, José; Oltra, Elisa; Aldana-Montes, José F.

Sep 2025

View article | Discussion on S4ME

Cohorts in this study

Phenotype: ME/CFS, ME/CFS - CCC criteria, ME/CFS - ICC Criteria, Post-exertional malaise (PEM)

ADAM10, AFF1, ARF3, B2M, BANF1, BCL11B, BIRC2, BIRC6, BRMS1, C11orf58, C1QA, CALCR, CASP14, CASP5, CBX3, CCL2, CCL20, CCL4, CCL8, CD274, CD3G, CD44, CD47, CD74, CDH11, CDKN1B, CEBPD, CHIA, COLEC12, COPS6, CSF3, CSNK2A1, CXCL2, CXCL3, DDX5, DES, DKC1, DLC1, EGR4, EIF3F, EIF4G2, EWSR1, F3, FAU, FNTA, FXYD5, HK2, HLA-DRB1, HNRNPA1, HNRNPA2B1, HSP90AA1, HTATIP2, IFNG, IKBKGP1, IL12B, IL1RN, IL24, IL27RA, IL6, INHBA, IRS1, ISG15, ITGB1, JAK2, JTB, KHDRBS1, KMT2C, LINC00921, MEF2C, MERTK, METAP2, MPG, MSH5, MTF2, MX1, NEUROG1, NFATC1, NME4, NOTCH1, NPM1, NPTX1, NTF3, OAS2, PABPC1, PARK7, PIM1, PLEKHG5, PMS2, POLL, PPP2R1A, PRKCB, PROX1, PTEN, PTX3, RAD50, RAD51B, RB1, RBBP5, RBBP7, RBBP8, RBP2, RIF1, RING1, RORC, RPL11, RPL14, RPL17, RPL19, RPL21, RPL28, RPL30, RPL34, RPL37, RPL9, RPS10, RPS11, RPS24, RPS25, RPS27A, RPS3A, RPSA, RUNX2, S100A4, SCN1A, SERPINB2, SERTAD1, SMNDC1, SNRNP200, SNX3, SOCS3, SPHK1, TAB2, TAL1, THAP11, THBS1, TNF, TNFRSF21, TOLLIP, TRADD, TRIM24, TYRP1, UCP1, USP22, VPS4A, ZBTB16, ZHX2, ZSCAN29

Phenotype: Fibromyalgia, Fibromyalgia - 1990 ACR (American College of Rheumatology) criteria, Fibromyalgia - 2011 ACR (American College of Rheumatology) criteria, ME/CFS, ME/CFS - CCC criteria, ME/CFS - ICC Criteria, Post-exertional malaise (PEM)

B2M, BCL11B, BRMS1, C1QA, CALCR, CASP5, CCL2, CCL8, CD274, CD3G, CDH11, CEBPD, COLEC12, CSF3, CXCL2, CXCL3, DKC1, DPPA4, EIF4B, EWSR1, F3, FAU, IL12B, IL1RN, IL6, ISG15, KLF10, LY96, MERTK, MTF2, MX1, NEUROG1, NFATC1, NOTCH1, NPM1, OAS2, PARK7, PIM1, PMS2, PPIAP34, PRDX1, PRKCB, PRKCZ, PROX1, PTX3, RAD51B, RBBP7, RBP2, RING1, RORC, RPL17, RPL18, RPL19, RPL21, RPL28, RPL30, RPL34, RPL37, RPL4, RPL9, RPS10, RPS11, RPS25, RPS27A, RPS3A, RPSA, RUNX2, SNX3, SOCS3, TAB2, TAL1, THBS1, TNF, TOLLIP

Phenotype: Fibromyalgia, Fibromyalgia - 1990 ACR (American College of Rheumatology) criteria, Fibromyalgia - 2011 ACR (American College of Rheumatology) criteria

ADAM10, AFF1, ARF3, B2M, BANF1, BCL11B, BIRC2, BRMS1, C11orf58, C1QA, CALCR, CASP14, CASP5, CBX3, CCL2, CCL20, CCL4, CCL8, CD274, CD3G, CD44, CD47, CD74, CDH11, CDKN1B, CEBPD, CHIA, COLEC12, COPS6, CSF3, CSNK2A1, CXCL2, CXCL3, DDX5, DES, DKC1, DLC1, DPPA4, EGR4, EIF3F, EIF4B, EIF4G2, EWSR1, F3, FAU, FNTA, FXYD5, HK2, HLA-DRB1, HLA-DRB3, HLA-DRB4, HNRNPA1, HNRNPA2B1, HSP90AA1, HTATIP2, IFNG, IKBKGP1, IL12B, IL1RN, IL24, IL6, INHBA, IRS1, ITGB1, JAK2, JTB, KHDRBS1, KLF10, KMT2C, LINC00921, MERTK, MPG, MTF2, MX1, NEUROG1, NFATC1, NME4, NOTCH1, NPM1, NPTX1, NTF3, OAS2, PABPC1, PBRM1, PIK3CA, PIM1, PLEKHG5, PMS2, POLL, PPIAP34, PPP2R1A, PRKCB, PRKCZ, PTEN, PTX3, RAD50, RAD51B, RB1, RBBP5, RBBP8, RBP2, RING1, RORC, RPL11, RPL14, RPL17, RPL18, RPL19, RPL21, RPL28, RPL30, RPL34, RPL37, RPL4, RPL9, RPS10, RPS11, RPS24, RPS25, RPS27A, RPS3A, RUNX2, S100A4, SCN1A, SERPINB2, SERTAD1, SMNDC1, SNRNP200, SNX3, SOCS3, SPHK1, TAB2, TAL1, THAP11, THBS1, TNF, TNFRSF21, TOLLIP, TRADD, TRIM24, TYRP1, UCP1, USP22, VPS4A, ZBTB16, ZHX2, ZSCAN29

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