Deep phenotyping of post-infectious myalgic encephalomyelitis/chronic fatigue syndrome

Authors: Walitt, Brian; Singh, Komudi; LaMunion, Samuel R.; Hallett, Mark; Jacobson, Steve; Chen, Kong; Enose-Akahata, Yoshimi; Apps, Richard; Barb, Jennifer J.; Bedard, Patrick; Brychta, Robert J.; Buckley, Ashura Williams; Burbelo, Peter D.; Calco, Brice; Cathay, Brianna; Chen, Li; Chigurupati, Snigdha; Chen, Jinguo; Cheung, Foo; Chin, Lisa M. K.; Coleman, Benjamin W.; Courville, Amber B.; Deming, Madeleine S.; Drinkard, Bart; Feng, Li Rebekah; Ferrucci, Luigi; Gabel, Scott A.; Gavin, Angelique; Goldstein, David S.; Hassanzadeh, Shahin; Horan, Sean C.; Horovitz, Silvina G.; Johnson, Kory R.; Govan, Anita Jones; Knutson, Kristine M.; Kreskow, Joy D.; Levin, Mark; Lyons, Jonathan J.; Madian, Nicholas; Malik, Nasir; Mammen, Andrew L.; McCulloch, John A.; McGurrin, Patrick M.; Milner, Joshua D.; Moaddel, Ruin; Mueller, Geoffrey A.; Mukherjee, Amrita; Muñoz-Braceras, Sandra; Norato, Gina; Pak, Katherine; Pinal-Fernandez, Iago; Popa, Traian; Reoma, Lauren B.; Sack, Michael N.; Safavi, Farinaz; Saligan, Leorey N.; Sellers, Brian A.; Sinclair, Stephen; Smith, Bryan; Snow, Joseph; Solin, Stacey; Stussman, Barbara J.; Trinchieri, Giorgio; Turner, Sara A.; Vetter, C. Stephenie; Vial, Felipe; Vizioli, Carlotta; Williams, Ashley; Yang, Shanna B.; Nath, Avindra

Nature Communications, 21 Feb 2024

View article | Discussion on S4ME


Cohorts in this study

Phenotype: ME/CFS, ME/CFS - IOM (Institute of Medicine) 2015 criteria, Post-exertional malaise (PEM)

A2M, ABL1, ADAMTS15, ADM, AGER, AHSG, AIF1, AIP, ALB, AMN, ANGPT4, ANP32B, ANXA1, APOB, APOE, ARG1, ASAH2, ATP5F1B, B2M, BCL2A1, BDNF, BGN, BMP1, BMPER, BMPR1A, C3, C4A, C4B, C9, CA9, CADM1, CAMK1, CAMK2B, CASP10, CAST, CCL11, CCL21, CCL3L1, CCNA2, CCNB1, CD209, CD226, CD300C, CD36, CD4, CD8A, CD93, CDH2, CDK1, CDK2, CFH, CFI, CHEK1, CHKB, CHL1, CLC, CLCF1, CLEC11A, CLU, CNDP1, CNDP2, CNTFR, CNTN1, CRLF1, CRYZL1, CSF1R, CST1, CST6, CTSB, CTSS, CXCL10, CXCL11, CXCL13, CXCL5, CXCL6, CXCL9, CXCR5, CYP3A4, DDC, DDR2, DDX19B, DKK3, DNAJB1, DUSP3, EFNA2, EFNB3, ENO1, ENPP7, EPB41, EPHA1, EPO, ERAP1, ESD, F7, F9, FCN1, FGF12, FGF5, FGF7, FGF8, FGF9, FGFR1, FN1, FRZB, FSTL1, FTH1, FTL, GDF11, GDNF, GFAP, GH1, GPC5, GPD1, GREM1, GSK3A, GSK3B, GZMA, H1-2, H2AZ1, HAVCR2, HBEGF, HGF, HHLA2, HK2, HPGD, HSPB1, HSPD1, IFNL1, IGFBP2, IGFBP4, IGFBP5, IGFBP6, IGHA1, IGHA2, IL17RB, IL1B, IL1RN, IL22RA1, IL25, IL3RA, IL9, IMPDH2, ITGA1, ITGB1, JAML, KAT6A, KIR3DS1, KLK12, KLK8, KLRK1, KPNB1, LAYN, LBP, LDHB, LGALS4, LRIG3, LRP1B, LTA, LTA4H, LTB, LUM, LYN, MAP2K1, MAP3K7, MAPKAPK2, MAPKAPK5, MATK, MBD4, MCL1, MIA, MMP16, MMP17, MMP2, MMP7, MSR1, MSTN, NCAM1, NCR3, NLGN4X, NOTCH2, NOTCH3, NPPB, NRCAM, NRXN3, NTN4, NXPH1, OMD, P4HB, PAK5, PARK7, PCSK9, PDCD1, PF4, PGD, PIK3CA, PIK3R1, PKM, PLA2G10, PLA2G5, PLAUR, PLG, PON1, PPID, PRKAA1, PRKAB1, PRKAG1, PRKCA, PRKCB, PRKCZ, PROC, PROS1, PRSS1, PRSS27, PTGS2, PTHLH, PTK6, PTN, RARRES2, ROBO3, RPS3A, RSPO2, RSPO3, SCARB2, SELL, SERPINA1, SFRP1, SH2D1A, SIRPA, SLAMF7, SMAD2, SOD1, SOD2, SPHK1, SPHK2, STAT1, STUB1, TAB1, THBS2, TIMP2, TKT, TNFAIP6, TNFRSF10D, TNFRSF13C, TNFRSF19, TNFRSF1A, TNFRSF1B, TNFRSF8, TNFSF13B, TNFSF9, TPO, TSLP, TYK2, UCHL1, VCAM1, WFIKKN1, XPNPEP1, ZNRF3


Notes

Data on study cohort phenotype
- All fulfilled IOM criteria from Supplementary Data 2D.

Gene data from:
- "Immune activation and sex-based differences in PI-ME/CFS" (CD56)
- Table S17 C-F (VIP scores? Maybe shouldn't be included.)