Single-cell transcriptomics of the immune system in ME/CFS at baseline and following symptom provocation

Authors: Vu, Luyen Tien; Ahmed, Faraz; Zhu, Hongya; Iu, David Shing Huk; Fogarty, Elizabeth A.; Kwak, Yeonui; Chen, Weizhong; Franconi, Carl J.; Munn, Paul R.; Tate, Ann E.; Levine, Susan M.; Stevens, Jared; Mao, Xiangling; Shungu, Dikoma C.; Moore, Geoffrey E.; Keller, Betsy A.; Hanson, Maureen R.; Grenier, Jennifer K.; Grimson, Andrew

Cell Reports Medicine, Jan 2024

View article | Discussion on S4ME


Cohorts in this study

Phenotype: ME/CFS, ME/CFS - CCC criteria, Post-exertional malaise (PEM)

ACADVL, ACLY, ACTL6A, ACTN4, ACTR2, ADA2, ADGRE5, ADSS2, AGA, AK2, AKR1A1, AKR7A2, ALDH3B1, ALDH9A1, ALDOA, ALDOC, ALOX5, ANKRD13A, ANP32A, ANP32B, ANP32E, ANPEP, AP2A2, AP2M1, APBB1IP, APEH, ARHGAP30, ARHGAP4, ARHGEF2, ARRB1, ARSA, ASAH1, ASH2L, ATIC, BIN2, BROX, BUB3, C11orf54, CALR, CAPZA1, CASP1, CASP6, CBL, CCDC47, CCL20, CCL3, CCL4, CCL4L2, CCL5, CD36, CD8A, CELF2, CES1, CHID1, CHMP4A, CNN2, CNPY2, COPB2, CPNE2, CS, CSF2, CSF3, CSNK2B, CTSB, CTSC, CTSD, CTSG, CTSH, CTSS, CTSZ, CX3CR1, CXCL1, CXCR4, CYBB, CYC1, CYCS, DBNL, DCTN1, DDB1, DDOST, DDT, DDX17, DDX5, DEK, DPYD, DSTN, DYSF, EEF1G, EFHD2, EIF2A, EIF3D, EIF3G, EIF3I, ELANE, ELOC, EMP3, ERLIN1, ERP44, ESD, FAH, FAM98B, FBP1, FKBP1A, FLII, FLNA, FLNB, FTL, GAK, GDI1, GGCT, GGH, GIMAP4, GLA, GLB1, GLO1, GLOD4, GLUD1, GMPPB, GNB1, GNB2, GNB4, GNS, GOT2, GPD2, GPI, GPX1, GRB2, GRHPR, GSR, GSTO1, GSTP1, H3-3A, H3-3B, H3C13, H3C14, H3C15, H6PD, HAAO, HADHB, HARS1, HCFC1, HCK, HDGF, HEBP1, HEBP2, HEXA, HEXB, HIBADH, HK2, HLA-A, HMGB1, HMGB2, HMGB3, HNRNPA0, HNRNPA1, HNRNPA2B1, HNRNPF, HPRT1, HSD17B10, HVCN1, IAH1, IDH1, IFI30, IGF2R, IGHG1, IGLC2, IKBKB, IL10RB, ILF3, IMPDH1, IMPDH2, ITGA5, ITGAL, ITGAM, JUP, KBTBD11, LAMP2, LAP3, LCP1, LMAN2, LRRC59, LSM2, LSM8, MAGOH, MAN2B1, MANF, MAPK1, MDH1, MDH2, METAP1, MOGS, MPO, MSN, MTAP, MTARC1, MTCH2, MYDGF, MYH14, MYH9, NAXE, NCF1, NCLN, NCSTN, NDUFS1, NIT1, NME2, NMT1, NOMO2, NPC2, NT5C2, NUDT21, NUP50, OSBPL8, P4HB, PARK7, PCMT1, PDIA4, PDXK, PEBP1, PECAM1, PEPD, PFDN2, PFN1, PGAM1, PGLS, PGRMC2, PHPT1, PLD3, PLEK, PLEKHO2, PPIA, PPIB, PPP2R2A, PRDX1, PRDX2, PRDX4, PREB, PREP, PRKAR2B, PRPS2, PSMA1, PSMA3, PSMA6, PSMB10, PSMB4, PSMB7, PSMB9, PSMC6, PTBP1, PTDSS1, PTGES3, PTK2B, PTPRC, PUDP, RAC1, RALB, RANBP2, RAP1B, RAVER1, RBM3, RCC1, RETN, RHOG, RHOT2, RNH1, ROCK1, RP2, RPA2, RPN1, RPS2, RRAGC, RSU1, RTCB, RTRAF, S100A4, SART3, SCCPDH, SCFD1, SCP2, SDCBP, SDF2L1, SDHA, SDHB, SEC13, SEC23B, SEC23IP, SEC31A, SELENOF, SELPLG, SERPINA1, SERPINB1, SERPINB6, SERPINB8, SF3A1, SH3BGRL3, SKAP2, SKIC8, SLC44A1, SND1, SNRPB, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPG, SNX27, SOD1, SOD2, SORL1, SPTAN1, SPTLC2, SRPRB, SSB, SSBP1, SSR1, STAT3, STRAP, STX3, STXBP5, SUN2, SURF4, TBCA, TES, TGFB1, THOP1, TKT, TLR1, TLR4, TLR5, TMED10, TMED7, TMED9, TMEM14C, TMEM205, TMEM33, TMSB4X, TMX4, TNFRSF1A, TOLLIP, TPD52L2, TPI1, TPM3, TPM4, TPP1, TRA2B, TRAPPC4, TST, TWF2, TXNDC17, TXNDC5, TXNRD1, U2AF2, UBA1, UBE2V1, UGGT1, UPF1, UQCR10, UROD, USP15, USP7, VAPA, VAT1, VCP, VDAC1, VPS26A, VPS35, XRCC6, YWHAG


Notes

Criteria of CCC from previous paper.

Data from:
- Figures 1F, 2F, 3C, 3F
- Figures S4H, S6C
- Data S10 (Where "diff_abund_adjpval" does not equal "Non-significant")