WASF3 disrupts mitochondrial respiration and may mediate exercise intolerance in myalgic encephalomyelitis/chronic fatigue syndrome

Authors: Wang, Ping-yuan; Ma, Jin; Kim, Young-Chae; Son, Annie Y.; Syed, Abu Mohammad; Liu, Chengyu; Mori, Mateus P.; Huffstutler, Rebecca D.; Stolinski, JoEllyn L.; Talagala, S. Lalith; Kang, Ju-Gyeong; Walitt, Brian T.; Nath, Avindra; Hwang, Paul M.

Proceedings of the National Academy of Sciences, 14 Aug 2023

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Cohorts in this study

Phenotype: Chronic fatigue, Li-Fraumeni syndrome (LFS)

EIF2S1, MAPK14, MT-CO1, MT-CO2, TP53, WASF3

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Phenotype: ME/CFS

COX17, EIF2AK3, HSPA5, MT-CO1, WASF3

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Notes

Unclear whether all with ME/CFS had PEM.

Data for LFS from:
- Section "Decreased Mitochondrial Function in a Patient with Chronic Fatigue."
- Section "Pharmacologic Inhibition of ER Stress Decreases WASF3 and Rescues Supercomplex Formation and Respiration."

Data for ME/CFS from:
- Section "WASF3 is Overexpressed in Skeletal Muscle of ME/CFS Patients and is Associated with ER Stress."
- Figure 5B