Abnormal T-Cell Activation And Cytotoxic T-Cell Frequency Discriminates Symptom Severity In Myalgic Encephalomyelitis/Chronic Fatigue Syndrome | Sick Genes

Abnormal T-Cell Activation And Cytotoxic T-Cell Frequency Discriminates Symptom Severity In Myalgic Encephalomyelitis/Chronic Fatigue Syndrome

Authors: Lee, Ji-Sook; Lacerda, Eliana; Kingdon, Caroline; Susannini, Giada; Dockrell, Hazel M; Nacul, Luis; Cliff, Jacqueline M

MedRxiv, 6 Jan 2025 (Preprint)

View article | Discussion on S4ME

Cohorts in this study

Phenotype: ME/CFS

CD38, CD69, EOMES, GZMB, IFNG, PDCD1, PRF1, TBX21, TNF

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Notes

Genes described in these sections:

Granzyme and/or perforin expressing CD8+ T cells and MAITs are reduced in people with ME-SA, ex vivo and following stimulation
T cells and NK cells from people with severe ME/CFS exhibit enhanced activation status
Proinflammatory cytokine production after stimulation is elevated in ME-SA