Actively protective combinatorial analysis: A scalable novel method for detecting variants that contribute to reduced disease prevalence in high-risk individuals

Authors: Sardell, J; Das, S; Taylor, K; Stubberfield, C; Malinowski, A; Strivens, M; Gardner, S

Artificial Intelligence in the Life Sciences, Jun 2025

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Phenotype: ME/CFS

CAMK1D, CAMK1G, CDC14A, DYM, EPB41L4B, GAB4, HGD, IFI27L1, POU6F1

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Notes

"15 SNPs identified in the actively protective analysis represent ‘critical SNPs’ as defined in Das at al. 2022. [...] Of these, 9 mapped to protein-coding genes, as listed in Table 2 below."