Autoantibody-Driven Monocyte Dysfunction in Post-COVID Syndrome with Myalgic Encephalomyelitis/Chronic Fatigue Syndrome

Authors: Hackel, Alexander; Sotzny, Franziska; Mennenga, Elise; Heidecke, Harald; Schulze-Foster, Kai; Fourlakis, Konstantinos; Lüders, Susanne; Grasshoff, Hanna; Rubarth, Kerstin; Konietschke, Frank; Lange, Tanja; Scheibenbogen, Carmen; Akbarzadeh, Reza; Riemekasten, Gabriela

MedRxiv, 13 Jan 2025 (Preprint)

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Phenotype: ME/CFS, ME/CFS - Canadian Consensus Criteria (CCC) 2003, Post-exertional malaise (PEM)

CCL13, CCL15, CCL22, CCL26, CCL5, CCL8, CXCL1, FGF9, IL1A, IL4, IL7, KITLG, NTF4, PDGFB, PIGF, PPBP, TGFB1, TGFB3, THPO, TNFSF14

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Notes

Based on:

Significant cytokines from figs 2B and 2D: "Exploration of cytokine expression between different groups: [...] pcME/CFS vs. PCS (B), [...] and pcME/CFS vs. HC (D). The volcano plot illustrates differences in cytokine expression between the groups after stimulation of monocytic cells with IgG."
Cytokines which correlate with symptoms in pcME/CFS from section "IgG-induced proteins correlate with distinct manifestations in nPCS and pcME/CFS"