Cerebrospinal fluid immune phenotyping reveals distinct immunotypes of myalgic encephalomyelitis/chronic fatigue syndrome
Authors: Bastos, Victoria C; Greene, Kerrie A; Tabachnikova, Alexandra; Bhattacharjee, Bornali; Sjögren, Per; Bertilson, Bo; Reifert, Jack; Zhang, Minlu; Kamath, Kathy; Shon, John; Gehlhausen, Jeff R; Guan, Leying; VanElzakker, Michael; Proal, Amy; Bragée, Björn; Iwasaki, Akiko
The Journal of Immunology,
15 May 2025
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Discussion on S4ME
Cohorts in this study
Phenotype:
ME/CFS,
ME/CFS - Canadian Consensus Criteria (CCC) 2003,
Post-exertional malaise (PEM)
CCL11,
CCL2,
CFP,
CSF1,
CX3CL1,
CXCL8,
FLT3LG,
IL10,
IL15,
IL5,
KITLG,
MMP1,
MMP10,
MMP2,
TNFSF10
Search for these genes
Notes
Based on:
- Decreased anti-CFP IgM in ME/CFS
- Increased TRAIL (TNFSF10) in ME/CFS
- Correlations for fractalkine and eotaxin with other cytokines only in controls
- MMPs and cytokines differentially expressed based on unsupervised clusters in ME/CFS