Charting the circulating proteome in ME/CFS using cross-system profiling to uncover mechanistic insights

Authors: Hoel, August; Hoel, Fredrik; Dyrstad, Sissel Elisabeth Furesund; Chapola, Henrique; Rekeland, Ingrid Gurvin; Risa, Kristin; Alme, Kine; Sørland, Kari; Brokstad, Karl Albert; Marti, Hans-Peter; Mella, Olav; Fluge, Øystein; Tronstad, Karl Johan

Cell Reports Medicine, 4 Mar 2026

View article | Discussion on S4ME


Cohorts in this study

Phenotype: ME/CFS, ME/CFS - Canadian Consensus Criteria (CCC) 2003, Post-exertional malaise (PEM)

ACTN2, ADH6, ADIPOQ, ALB, ALDOA, AMBP, ANPEP, ANTXR2, APCS, APOB, APOD, ARG1, ARHGAP26, ARHGAP36, ARHGDIB, ARID3C, ARRB1, ART3, ATOH1, ATP5IF1, BASP1, BCL2, BCL7A, BEND6, BHMT2, BMP4, BPI, C3, C6, C6orf58, CA6, CANT1, CBS, CCL25, CD1B, CD2, CD300LB, CD3G, CD96, CEACAM4, CELF2, CFD, CFP, CHMP1B, CHST12, CKM, CLIC5, CMPK1, CNP, COMP, COQ10A, COX7A1, COXFA4L3, CPLX1, CPM, CRABP2, CSF3R, CTSG, CTSH, CXADR, DEFA5, DHRS11, DLL1, DPYSL3, DUSP29, EFNA1, EHD3, ELANE, ENPP5, EPHA1, EREG, ERP29, ETNK2, F9, FABP1, FABP3, FABP4, FAM20A, FAM221B, FAM3D, FAP, FDCSP, FEV, FGD2, FGF21, FGG, FOLR3, FSTL1, FYN, FZD2, FZD8, GAPDH, GAS6, GM2A, GRAP2, GRIA4, GZMK, H1-10, H1-2, H2AC1, H2AC11, H2AZ1, H2BC12, H2BC21, H2BC26, HEPHL1, HGF, HTR7, ID2, IFI16, IGFLR1, IGHD, IGHG2, IGHM, IL26, IL36A, IL36G, IL4I1, IL5RA, KLRC3, KRT1, KRT20, LCE3B, LCN2, LDHB, LEAP2, LEP, LGALS3, LIPG, LMAN2, LRRC25, LTF, MB, MCTS1, MGP, MMP17, MMP9, MNDA, MPO, MTHFS, MUSTN1, MYBPC1, MYL12A, MYOM2, NAMPT, NLRP4, NRGN, NT5C1A, NTNG1, OCRL, OGN, OIT3, PADI4, PCDH8, PCSK1N, PELI1, PGAM2, PGD, PGLYRP1, PGRMC1, PI3, PLA2G10, PLA2G2A, PPM1F, PRKCG, PRKCQ, PROC, PRTN3, PSMB3, PTP4A3, RAB31, RAB3C, RAC2, RARRES2, REG4, RIDA, RNASE3, RRM2, SERPINA9, SFTPD, SH3BGRL2, SH3GL3, SLAMF1, SMIM24, SNCA, SPI1, SPON2, SRC, SRL, STMN4, SULT4A1, TAGLN3, TAT, TCN1, TFPI, TGFA, TIMD4, TKT, TMED9, TMEM52, TMOD2, TMPRSS15, TNFRSF13B, TNFRSF9, TNFSF14, TPM2, TRABD2A, TRAPPC3, TRIM40, UPP2, VHLL, VIM, VSIG4, VWC2, WWP1, YY1

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Notes

Genes shown in: - Figs 1E, 1F, 4C

FDR Significant gene names comparing ME/CFS to HC from: - Figs 4D, 6C, 6D