Circulating cell-free RNA signatures for the characterization and diagnosis of myalgic encephalomyelitis/chronic fatigue syndrome
Authors: Gardella, Anne E.; Eweis-LaBolle, Daniel; Loy, Conor J.; Belcher, Emma D.; Lenz, Joan S.; Franconi, Carl J.; Scofield, Sally Y.; Grimson, Andrew; Hanson, Maureen R.; De Vlaminck, Iwijn
Proceedings of the National Academy of Sciences,
11 Aug 2025
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Discussion on S4ME
Cohorts in this study
Phenotype:
ME/CFS,
ME/CFS - Canadian Consensus Criteria (CCC) 2003,
ME/CFS - IOM 2015,
Post-exertional malaise (PEM)
CCL3,
CCR7,
CD109,
COL1A1,
FCRL5,
IFNLR1,
IL18R1,
MT-TH,
MT-TL1,
MT-TS2,
MT-TT,
MT-TV,
MTATP8P1,
MTG1,
MTND1P23,
MTND6P3,
MTRNR2L3,
PRF1,
TGFB2
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Notes
Several genes highlighted in text, for example: "Genes such as IL18R1, CCR7, FCRL5, PRF1, and IFNLR1 were more abundant in cases [...]"