Circulating Levels of SMPDL3B Define Metabolic Endophenotypes and Subclinical Kidney Alterations in Myalgic Encephalomyelitis

Authors: Rostami-Afshari, Bita; Elremaly, Wesam; McGregor, Neil R.; Huang, Katherine Jin Kai; Armstrong, Christopher W.; Franco, Anita; Godbout, Christian; Elbakry, Mohamed; Abdelli, Rim; Moreau, Alain

International Journal of Molecular Sciences, 12 Sep 2025

View article | Discussion on S4ME

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Phenotype: ME/CFS, ME/CFS - Canadian Consensus Criteria (CCC) 2003, Post-exertional malaise (PEM)

SMPDL3B

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Notes

Gene based on main result: "ME patients exhibited significantly lower urine-to-plasma ratios of soluble SMPDL3B and reduced renal clearance"