Deficient TRPM3-linked mitochondrial Ca2+ influx in natural killer cells associated with myalgic encephalomyelitis/chronic fatigue syndrome

Authors: Magawa, Chandi Tabeth; Eaton-Fitch, Natalie; Muraki, Katsuhiko; Marshall-Gradisnik, Sonya

BMC Immunology, 23 May 2026

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Phenotype: ME/CFS, ME/CFS - Canadian Consensus Criteria (CCC) 2003, ME/CFS - International Consensus Criteria (ICC), Post-exertional malaise (PEM)

TRPM3

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Notes

Based on one of the main findings: "TRPM3-dependent cytosolic and mitochondrial Ca2+ mobilisation (P < 0.015) were significantly reduced with a shorter T1/2 response (p < 0.02) in ME/CFS compared to HC."