Development and validation of blood-based diagnostic biomarkers for Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) using EpiSwitch® 3-dimensional genomic regulatory immuno-genetic profiling

Authors: Hunter, Ewan; Alshaker, Heba; Bundock, Oliver; Weston, Cicely; Bautista, Shekinah; Gebregzabhar, Abel; Virdi, Anya; Croxford, Joseph; Dring, Ann; Powell, Ryan; Vugrinec, Dominik; Kingdon, Caroline; Wilson, Carol; Dowrick, Sarah; Green, Jayne; Akoulitchev, Alexandre; Pchejetski, Dmitri

Journal of Translational Medicine, 8 Oct 2025

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Cohorts in this study

Phenotype: ME/CFS

ACYP1, ADGRF4, AMHR2, EFCAB12, EIF2B2, FAM13A, H1-10, HERC3, HMCES, KCNJ16, KCNJ2, KIR2DL3, KIR3DL3, KLRG1, LILRA1, LILRA2, LILRB1, LILRB4, M6PR, MAP2K6, MAP3K12, MLH3, NAP1L5, NDNF, OPN5, PADI1, PADI2, PADI3, PADI4, PADI6, PCBP2, PGF, PHC1, PRR13, PTCHD4, QRFPR, SP1, TNIP3, ZC2HC1C

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Notes

Genes from Table S1: "Genetic locality of the top 10 markers/probes that mostly impacted on the model of the 200-marker set"