Elevated serum levels of interleukin-11 and matrix metalloproteinase-9 in myalgic encephalomyelitis/chronic fatigue syndrome

Authors: Chinnappan, Baskaran; Kempuraj, Duraisamy; Aenlle, Kristina K.; Middleton, Ashley; Day, Katie S.; Kothuru, Sai Puneeth; Joshi, Rhitik Samir; Klimas, Nancy G.; Theoharides, Theoharis C.

Frontiers in Immunology, 5 Jun 2026

View article | Discussion on S4ME

Cohorts in this study

Phenotype: ME/CFS, ME/CFS - Canadian Consensus Criteria (CCC) 2003, ME/CFS - Fukuda 1994 (CDC) Criteria, Post-exertional malaise (PEM)

IL11, MMP9

Search for these genes

Notes

Main finding: "There was a significant increase in serum levels of IL-11 and MMP-9 in ME/CFS patients compared to control subjects."