Exploratory study on autoantibodies to arginine-rich human peptides mimicking Epstein-Barr virus in women with post-COVID and myalgic encephalomyelitis/chronic fatigue syndrome

Authors: Hoheisel, Friederike; Fleischer, Kathrin Maria; Rubarth, Kerstin; Sepúlveda, Nuno; Bauer, Sandra; Konietschke, Frank; Kedor Peters, Claudia; Stein, Annika Elisa; Wittke, Kirsten; Seifert, Martina; Bellmann-Strobl, Judith; Mautner, Josef; Behrends, Uta; Scheibenbogen, Carmen; Sotzny, Franziska

Frontiers in Immunology, 19 Sep 2025

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Phenotype: ME/CFS

ADRA1B, ADRA1D, ADRA2C, SLC24A3, SRRM3, TSPYL2, TSPYL5

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Notes

Significantly higher IgG reactivity to genes from fig. 2D, 2G.
"Antibodies targeting ADRA proteins were present in 20 – 40% of the HCs, but were significantly more frequent (Figure 4C) [... in ...] ME/CFS patients".