Extracellular vesicle proteomics uncovers energy metabolism, complement system, and endoplasmic reticulum stress response dysregulation postexercise in males with myalgic encephalomyelitis/chronic fatigue syndrome | Sick Genes

Extracellular vesicle proteomics uncovers energy metabolism, complement system, and endoplasmic reticulum stress response dysregulation postexercise in males with myalgic encephalomyelitis/chronic fatigue syndrome

Authors: Glass, Katherine A.; Giloteaux, Ludovic; Zhang, Sheng; Hanson, Maureen R.

Clinical and Translational Medicine, May 2025

View article | Discussion on S4ME

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Phenotype: ME/CFS, ME/CFS - Canadian Consensus Criteria (CCC) 2003, Post-exertional malaise (PEM)

ACLY, ACTN3, ACTR1A, ADD1, ADH5, AK1, AKR1A1, ANXA2, ANXA3, ARCN1, ARF6, ARHGAP18, ARHGDIA, ARPC4, ARPC5, ATP5PB, BLMH, CA2, CALR, CAPN1, CAPNS1, CAPZA2, CAVIN2, CCL5, CCT4, CCT7, CD84, CLTA, CMPK1, CNP, CNPY2, CRLF3, CS, DAB2, DAPP1, DARS1, DLST, DMTN, DNAJB11, DNM2, DSG1, EHD1, EHD3, ENO2, EPS15L1, ERBIN, ERP29, ERP44, FCN2, FERMT3, FKBP3, G6PD, GGCT, GLOD4, GMPR, GNB1, GP1BA, GPI, GRIPAP1, GSTM3, GSTP1, HNRNPK, HPRT1, HSP90AB1, HSPA5, HSPB1, HYOU1, IDH1, INPP4B, IPO7, ITGB1, KPNB1, KTN1, LCP1, LDHA, MAGED2, MAP2K3, MAPK14, MAPRE1, MCTS1, MPST, NAP1L4, NHERF1, NME1, NSF, NSFL1C, OSTF1, P4HB, PAFAH1B1, PAICS, PARVB, PCSK6, PDCD10, PDCD6IP, PDIA4, PEBP1, PECAM1, PFDN6, PGD, PGK1, PIP4K2A, PLS3, PPIB, PPIF, PPP1R14A, PRDX1, PRDX6, PRKAR2A, PRUNE1, PSMA4, PSMA5, PSMC6, PSTPIP2, PTGES3, PTPN11, PYGL, RAB7A, RAB8B, RAC1, RAP1A, RDX, RGCC, RGS18, RRAS, SAR1A, SCP2, SCRN1, SEC22B, SERPINB9, SERPINF1, SH3BGRL2, SNCA, STIP1, STK38, STRAP, SYNCRIP, SYTL4, TALDO1, TAOK3, TBCA, TFG, TFRC, TJP2, TKT, TMEM40, TPI1, TPM3, TPT1, TSN, TUBB6, TXNDC5, UBA52, UBE2L3, UGGT1, UNC13D, USO1, USP14, VBP1, VIM, XPNPEP1, XPO1, YWHAE

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Notes

Proteins from:

"The differentially abundant proteins (DAPs) identified between ME/CFS and controls at each time point are illustrated in Figure 3A"
Fig 4A: "Changes in EV protein levels between ME/CFS and controls over time postexercise."
"Supplementary Table S7: EV Proteins showing significant correlations with metrics of disease severity in ME/CFS patients (|R| > 0.8, q-value < 0.1), related to Figures 5B and C"
"Supplementary Table S9: EV Proteins showing significant correlations with ME/CFS specific symptoms(|R| > 0.8, q-value < 0.1), related to Figures 6A-C"
"Supplementary Table S10: List of the 68 EV Proteins showing significant correlations with unrefreshing sleep in ME/CFS patients (|R| > 0.8, q-value < 0.1), related to Figure 7"