Haptoglobin phenotypes and structural variants associate with post-exertional malaise and cognitive dysfunction in myalgic encephalomyelitis

Authors: Moezzi, Atefeh; Ushenkina, Anastasiya; Widgren, Anna; Bergquist, Jonas; Li, Peng; Xiao, Wenzhong; Rostami-Afshari, Bita; Leveau, Corinne; Elremaly, Wesam; Caraus, Iurie; Franco, Anita; Godbout, Christian; Nepotchatykh, Oleg; Moreau, Alain

Journal of Translational Medicine, 28 Aug 2025

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Phenotype: ME/CFS, ME/CFS - Canadian Consensus Criteria (CCC) 2003, Post-exertional malaise (PEM)

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Notes

Main finding: "ME patients demonstrated a significant reduction in Hp levels following post-exertional stress. Lower baseline Hp concentrations were associated with impaired cognitive performance."