Heightened innate immunity may trigger chronic inflammation, fatigue and post-exertional malaise in ME/CFS | Sick Genes

Heightened innate immunity may trigger chronic inflammation, fatigue and post-exertional malaise in ME/CFS

Authors: Che, Xiaoyu; Ranjan, Amit; Guo, Cheng; Zhang, Keming; Goldsmith, Rochelle; Levine, Susan; Moneghetti, Kegan J.; Zhai, Yali; Ge, Liner; Mishra, Nischay; Hornig, Mady; Bateman, Lucinda; Klimas, Nancy G.; Montoya, Jose G.; Peterson, Daniel L.; Klein, Sabra L.; Fiehn, Oliver; Komaroff, Anthony L.; Lipkin, W. Ian

npj Metabolic Health and Disease, 3 Sep 2025

View article | Discussion on S4ME

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Phenotype: ME/CFS

ADGRD1, AOC2, BATF3, C1R, CALCR, CD93, CDH1, CDH5, CFHR4, CLEC3B, CNTN4, COMP, CPQ, CSF1, CSF2, CUTC, CXCL5, CXCL8, EIF1, ELAVL2, EPHA4, ERVV-1, GDF15, GPX5, HIPK3, HTRA1, IFNG, IL13, IL17A, IL1B, IL2, IL23A, IL6, KDR, LRP8, MAPK6, MYOC, PLS1, PROC, PSPH, RAMP3, S100A8, SELL, TFF1, TNF, UBE2D3

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Notes

Proteins mentioned in section "Heightened cytokine responses to SEB and HKCA in ME/CFS"
All significant proteins from figures 2E and 2F: "Volcano plots showing BayesFactors (BFs) of proteomic analytes in plasma comparing ME/CFS vs. HC (E) before and (F) after exercise"