Identification of novel reproducible combinatorial genetic risk factors for myalgic encephalomyelitis in the DecodeME patient cohort and commonalities with long COVID

Authors: Sardell, J. M.; Das, S.; Pearson, M.; Kolobkov, D.; Malinowski, A. R.; Fullwood, L. M.; Sanna, M.; Baxter, H.; McLellan, K.; Natt, M.; Lamirel, D.; Chowdhury, S.; Strivens, M. A.; Gardner, S.

Journal of Translational Medicine, 21 Apr 2026

View article | Discussion on S4ME


Cohorts in this study

Phenotype: ME/CFS

AAMDC, ABCA1, ABCC6, ABHD12, ACOX3, ACTL8, ACTR3C, ADAM12, ADAM28, ADAMTS2, ADAMTS9, ADGRL2, ADIPOQ, ADPRH, ADTRP, AFF1, AFF3, AKAP2, AKAP6, ALDOB, ANGPT1, ANKS1B, ANO3, ANO4, ARB2A, ARHGAP8, ASB2, ASB3, ASIC2, ASXL3, ATCAY, ATXN1, BAG6, BCCIP, BNC2, BRF1, BTBD2, BTBD7, BTBD9, C18orf63, C1orf87, C20orf173, C3, C5orf47, CACNA1A, CACNA1D, CACNA2D3, CACNB2, CAMTA1, CBFA2T3, CCDC148, CCDC149, CCDC171, CCDC85A, CD22, CD82, CD8B, CDH12, CDH13, CDK14, CELF2, CEP19, CGNL1, CH25H, CHCHD6, CHL1, CKAP4, CLCN6, CNTN4, COL19A1, COL27A1, COL4A4, COLEC12, COX17, CPVL, CREB5, CRYBG2, CSE1L, CSGALNACT1, CSMD1, CSMD2, CTNNA2, CYB5RL, CYFIP1, CYP7B1, DAB1, DCC, DDAH1, DDR1, DENND1A, DENND2A, DHX32, DISC1, DISP2, DLC1, DLGAP2, DMAC1, DNAH11, DNAJA4, DNAJC25, DOCK2, DPP3, DPP6, DSCAML1, EEPD1, EFCAB5, EHMT1, EPHB1, ERBB4, EYA1, F13A1, FAM53B, FARP1, FBXO7, FGF12, FHIT, FNTB, FOCAD, FRAS1, FREM3, FRMD4A, FTO, FUT8, GABBR1, GABBR2, GABRB1, GALNT18, GCNT1, GINS1, GNL3, GPSM2, GRIA1, GRIK1, GRK4, GRM7, GUCY1A2, H2BC6, H2BC7, HACD1, HMGCLL1, HPN, HS3ST4, IGF1R, IGF2BP3, INPP4B, JAKMIP2, KANSL1, KAZN, KCNIP4, KCNJ16, KCNMA1, KIF26B, KLF12, KLHDC4, KRT86, KSR1, LAIR1, LOXL2, LPA, LPP, LRMDA, LRRC74A, LYPD5, MAML2, MAPK9, MAX, MDGA2, MED13L, MED25, MICB, MMAB, MOV10, MRPL37, MSI2, MSR1, MTMR7, MTX2, MUC16, MYO3B, MYT1L, NAV3, NBEAL2, NCKAP5, NCOR2, NDST3, NECTIN1, NEDD9, NELL1, NFIA, NLGN1, NOP9, NOS1AP, NTN1, NTRK3, OPCML, OR10A6, OR5AC2, OR5V1, PACRG, PARD3B, PARM1, PARS2, PAX5, PCDH9, PCSK2, PCSK6, PDE1C, PDIA3, PDZD2, PEBP4, PIGX, PITPNC1, PKM, PLCB1, PLD5, PLXNA2, POPDC2, POR, PPM1N, PPP1R16B, PPP1R36, PRKG1, PRODH, PSMB9, PTPRD, PTPRG, PUS10, RADIL, RAI14, RAP1GAP2, RASGEF1B, RASGRF2, RB1CC1, RBFOX1, RERE, RERGL, RGS7, RHBDD2, RHBDL3, RIMS2, RNF150, RRBP1, RYR2, RYR3, SAMD5, SASH1, SCAMP3, SCUBE1, SEC23IP, SEL1L, SEZ6L, SFMBT2, SFTA2, SGSM2, SH3PXD2A, SH3RF3, SLC17A2, SLC25A21, SLC25A24, SLC28A1, SLC35F3, SLC38A4, SLC39A12, SLC5A10, SLCO2A1, SMARCA2, SNTG1, SNX29, SNX31, SORCS2, SOX5, SPMIP2, SPOCK1, SPOCK3, SPTBN5, SPTLC3, SRGAP1, ST6GAL1, ST8SIA1, STAB1, STIM2, STOX2, SUB1, SUCLA2, SULT1C3, SYN3, SYNPR, SYTL3, TACC1, TACR1, TAP1, TBXAS1, TENM2, TENM3, THSD7A, TIAM2, TLR3, TM7SF3, TMEM132C, TMEM260, TMEM63C, TMTC1, TNIK, TNS1, TOX3, TPH2, TPX2, TRIM26, TRIM31, TRIM9, TRPM3, TSKU, TSPAN5, TTC39C, TTLL11, TUBB, UGGT1, UNC93A, UROS, USH2A, USP30, USP45, USP47, UTRN, VIT, WWOX, XKR3, XYLT1, YWHAB, ZC3H3, ZC3H7A, ZIC4, ZMAT4, ZMIZ1, ZNF282, ZNF283, ZNF385B, ZNF385D, ZNF423, ZNF577, ZNF71, ZPLD1, ZSCAN5C, ZZEF1


Notes

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