Initial findings from the DecodeME genome-wide association study of myalgic encephalomyelitis/chronic fatigue syndrome

Authors: Boutin, Thibaud; Bretherick, Andrew D.; Dibble, Joshua J.; Ewaoluwagbemiga, Esther; Northwood, Emma; Samms, Gemma L.; Vitart, Veronique; Almelid, Øyvind; Baker, Tom; Clyde, Malgorzata; Connolly, Anne; Garcia, Diana; Kerr, Shona M.; Tripp, Claire; Wolfe, Jareth C.; Goold, Jackie; Hoyes, Gemma; Leary, Sian; McGrath, Simon J.; Milton, Julie; Redshaw, Anna; Wilson, Jim M.; Baxter, Helen; Boobyer, Danielle; Dransfield, Claire; Lamirel, Daphne; Lewis, Isabel; Muirhead, Nina; Ponting, Ella; Shepherd, Charles; Turner, Alice; Baby, Sumy V.; Beentjes, Sjoerd; Ireland, John; Khamseh, Ava; McDowall, Ewan; Perry, David; Slaughter, Joshua; Abner, Erik; Boer, Cindy G.; Finer, Sarah; Haapaniemi, Hele; Ollila, Hanna M.; Pollack, Beth; Rosmalen, Judith; Romppanen, Erika; Saafi, Sirine; Saxena, Richa; Sinnott-Armstrong, Nasa; Tervi, Anniina; Urpa, Lea; Valliere, Jesse; van Heel, David A.; Chowdhury, Sonya; Devereux-Cooke, Andy; Ponting, Chris P.

8 Aug 2025 (Preprint)

View article | Discussion on S4ME


Cohorts in this study

Phenotype: ME/CFS, Post-exertional malaise (PEM)

ABT1, ANKRD45, ARFGEF2, B4GALT5, BTN2A2, BTN3A3, CA10, CACNA1E, CCDC92, CCPG1, CDK5RAP1, CSE1L, DARS2, DCC, DDX27, DNAH10, DNAJC1, ECI2, FBXL4, GPR52, H4C8, HFE, HMGN4, HTT, KLHL20, LRRC7, LRRIQ3, MLLT10, MMS22L, MRPL39, NEGR1, OLFM4, PCDH17, PEBP1, PLCL1, POU3F2, PRDX6, PTGIS, RABGAP1L, RC3H1, SERPINC1, SHISA6, SLC2A14, SLC9C2, SOX6, STAU1, SUDS3, TAOK3, TNFSF4, TRIM38, UNC13C, VRK2, VSIG10, ZBTB37, ZNF311, ZNF322, ZNF644, ZNF664, ZNFX1

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Notes

Tier 1 and 2 genes, significant MAGMA genes, and the one or two genes nearest to each of the top 25 loci.