Killer cell immunoglobulin-like receptor (KIR) alleles suggested to be associated with myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS)

Authors: Ramadan, Donia Jamal; Kichula, Katherine M.; Tao, Sudan; Porfilio, Timothy; Lande, Asgeir; Fluge, Øystein; Mella, Olav; Strand, Elin Bolle; Saugstad, Ola Didrik; Norman, Paul J.; Lie, Benedicte A.; Viken, Marte K.

Brain, Behavior, and Immunity, Nov 2025

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Phenotype: ME/CFS, ME/CFS - Canadian Consensus Criteria (CCC) 2003, Post-exertional malaise (PEM)

KIR3DL1, KIR3DL2, KIR3DL3

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Notes

Based on: "Three alleles were more frequent in ME/CFS (Table 2), i.e. KIR3DL3002 (OR = 1.43, p = 0.009), KIR3DL1020 (OR = 2.20, p = 0.01) and KIR3DL2009 (OR = 1.56, p = 0.01). Two alleles had a reduced frequency among patients; i.e. KIR3DL3013 (OR = 0.60, p = 0.005) and KIR3DL2*010 (OR = 0.46, p = 0.0005)."