Low-dose rapamycin alleviates clinical symptoms of fatigue and PEM in ME/CFS patients via improvement of autophagy: a pilot study

Authors: Ruan, Brian T.; Bulbule, Sarojini; Gile, Brooke; Reyes, Amy; Chheda, Bela; Bateman, Lucinda; Bell, Jennifer; Yellman, Brayden; Grach, Stephanie L.; Berner, Jon; Peterson, Daniel L.; Kaufman, David; Roy, Avik; Gottschalk, C. Gunnar

Journal of Translational Medicine, 21 Oct 2025

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Phenotype: ME/CFS, ME/CFS - Canadian Consensus Criteria (CCC) 2003, ME/CFS - IOM 2015 Criteria, Post-exertional malaise (PEM)

ATG13, BECN1

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Notes

Based on correlations of changes in proteins with changes in clinical measures, from figures 2E and 2F.