Mapping the complexity of ME/CFS: Evidence for abnormal energy metabolism, altered immune profile, and vascular dysfunction

Authors: Heng, Benjamin; Gunasegaran, Bavani; Krishnamurthy, Shivani; Bustamante, Sonia; Pires, Ananda Staats; Chow, Sharron; Ahn, Seong Beom; Paul-Heng, Moumita; Maciver, Yolande; Smith, Kirsten; Tran, Denise P.; Howley, Peter P.; Bilgin, Ayse Aysin; Sharland, Alexandra; Schloeffel, Richard; Guillemin, Gilles J.

Cell Reports Medicine, Dec 2025

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Phenotype: ME/CFS, ME/CFS - Canadian Consensus Criteria (CCC) 2003, Post-exertional malaise (PEM)

B2M, CDH5, CFHR2, CFHR5, DNAJC2, EFEMP1, FETUB, FN1, IGHA1, IGHG2, IGHG3, IGHV3-74, IGHV5-51, IGKC, IGKV1-17, IGKV6-21, IGLL1, LYVE1, MASP1, PCYOX1, PIEZO1, PIGR, PRG4, PROC, SHBG, THBS1, VASN, VWF

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Notes

Proteins from Table 2: "Differentially expressed plasma proteins between ME/CFS and healthy controls"