ME/CFS and PASC Patient-Derived Immunoglobulin Complexes Disrupt Mitochondrial Function and Alter Inflammatory Marker Secretion

Authors: Liu, Zheng; Hollmann, Claudia; Kalanidhi, Sharada; Lamer, Stephanie; Schlosser, Andreas; Basens, Emils Edgars; Nikolayshvili, Georgy; Sokolovska, Liba; Riemekasten, Gabriela; Rust, Rebekka; Bellmann-Strobel, Judith; Paul, Friedemann; Naviaux, Robert K; Nora-Krukle, Zaiga; Sotzny, Franziska; Scheibenbogen, Carmen; Prusty, Bhupesh K

10 Aug 2025 (Preprint)

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Phenotype: ME/CFS, ME/CFS - Canadian Consensus Criteria (CCC), Post-exertional malaise (PEM)

ARG1, AZU1, CFHR5, CPN1, DSC1, EEA1, FCN2, FGG, GRN, HBA2, HSP90AB1, IGHV1-58, IGHV1-69-2, IGHV3-16, IGHV3-66, IGKV3-7, IL1B, IL5, ITPR3, KLKB1, LMNA, LTA, LYZ, MPO, PGLYRP2, PPL, PSMD6, SERPINA1, SERPINB3, SPEG, TTR, VWF, ZNF185

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Notes

Genes that are described as different from healthy controls in figs 5, 6, 7.