Metabolic adaptation and fragility in healthy 3D <i>in vitro</i> skeletal muscle tissues exposed to chronic fatigue syndrome and Long COVID-19 sera

Authors: Mughal, Sheeza; Andújar-Sánchez, Félix; Sabater-Arcis, Maria; Garrabou, Glória; Fernández-Solà, Joaquim; Alegre-Martin, Jose; Sanmartin-Sentañes, Ramon; Castro-Marrero, Jesús; Esteve-Codina, Anna; Casals, Eloi; Fernández-Costa, Juan M; Ramón-Azcón, Javier

Biofabrication, 8 Aug 2025

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Phenotype: ME/CFS, ME/CFS - International Consensus Criteria (ICC), Post-exertional malaise (PEM)

AGL, AIFM1, ATP2A1, ATP2B4, ATP5F1A, ATP5MF, CYCS, DNM1, ENDOG, ENO3, ESR2, FHL1, HTRA2, IDH2, MDH1, MDH2, MFN2, MT-ATP6, MT-ATP8, MT-CO1, MT-CO2, MT-CO3, MT-CYB, MT-ND1, MT-ND2, MT-ND3, MT-ND4, MT-ND4L, MT-ND5, MT-ND6, MTIF2, MTOR, NDUFAF1, NDUFB7, NOG, OGDH, PDHA1, PDK3, PDK4, PFKM, PKM, PRKAA1, PRKACA, SMYD1, SOD1, SOD2, SOD3, SUCLG1, SUCLG2, TOMM20

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Notes

Genes transcribed from figure 4I: "Heatmap of differentially expressed genes from RNASeq"