Metabolic profiling indicates impaired pyruvate dehydrogenase function in myalgic encephalopathy/chronic fatigue syndrome

Authors: Fluge, Øystein; Mella, Olav; Bruland, Ove; Risa, Kristin; Dyrstad, Sissel E.; Alme, Kine; Rekeland, Ingrid G.; Sapkota, Dipak; Røsland, Gro V.; Fosså, Alexander; Ktoridou-Valen, Irini; Lunde, Sigrid; Sørland, Kari; Lien, Katarina; Herder, Ingrid; Thürmer, Hanne; Gotaas, Merete E.; Baranowska, Katarzyna A.; Bohnen, Louis M.L.J.; Schäfer, Christoph; McCann, Adrian; Sommerfelt, Kristian; Helgeland, Lars; Ueland, Per M.; Dahl, Olav; Tronstad, Karl J.

JCI Insight, 22 Dec 2016

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Phenotype: ME/CFS, ME/CFS - Canadian Consensus Criteria (CCC), Post-exertional malaise (PEM)

MPC1, PDHA1, PDK1, PDK2, PDK4, PPARD, SIRT4

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Notes

Genes described in section "PDH-related gene expression (mRNA) in PBMCs."