Oxidative stress is a shared characteristic of ME/CFS and Long COVID

Authors: Shankar, Vishnu; Wilhelmy, Julie; Curtis, Ellis J; Michael, Basil; Cervantes, Layla; Mallajosyula, Vamsee; Davis, Ronald W; Snyder, Michael; Younis, Shady; Robinson, William H; Shankar, Sadasivan; Mischel, Paul S; Bonilla, Hector; Davis, Mark M

Proceedings of the National Academy of Sciences, 25 Aug 2025

View article | PubMed | Discussion on S4ME

Cohorts in this study

Phenotype: ME/CFS, ME/CFS - Canadian Consensus Criteria (CCC) 2003, ME/CFS - Fukuda 1994 (CDC) Criteria, ME/CFS - International Consensus Criteria (ICC), Post-exertional malaise (PEM)

GPX4

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Phenotype: ME/CFS, ME/CFS - Canadian Consensus Criteria (CCC) 2003, Post-exertional malaise (PEM)

PLA2G4A

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Notes

"Our staining showed LC and ME/CFS donor lymphocytes have significantly higher (1.77× and 1.9×, respectively) GPX4 levels (Fig. 4E), compared to HC T cells."
"We found that PLA2G4A, a calcium-dependent cytosolic phospholipase implicated with eicosanoid metabolism, has significantly higher transcript levels in ME/CFS donors compared to controls"