Skewing of the B cell receptor repertoire in myalgic encephalomyelitis/chronic fatigue syndrome

Authors: Sato, Wakiro; Ono, Hirohiko; Matsutani, Takaji; Nakamura, Masakazu; Shin, Isu; Amano, Keiko; Suzuki, Ryuji; Yamamura, Takashi

Brain, Behavior, and Immunity, Jul 2021

Based on:

"the expression of IGHV1-3, 3-30, 3-30-3, and 3-49 was significantly increased in ME/CFS patients compared with HCs. The expression of IGHD1-26 and IGHJ6 was also significantly increased in ME/CFS patients."
"The frequency and the expression level of CD40+ PBs was significantly increased in ME/CFS patients compared with HCs"
"Significantly upregulated genes were MX1, IFI16 (type I interferon [IFN]-inducible genes), and BCL2L11 (apoptosis-related gene)."