Systematic Examination of Gene Expression and Proteomic Evidence Across Tissues Supports the Role of Mitochondrial Dysregulation in ME/CFS
Authors: Keele, Gregory R.; Enger, Mike; Barnette, Quinn; Ruiz-Esparza, Roman; Alvarado, Manuel; Mathur, Ravi; Stratford, Jeran K.; Giamberardino, Stephanie N.; Brown, Linda Morris; Webb, Bradley T.; Carnes, Megan Ulmer
International Journal of Molecular Sciences,
19 Feb 2026
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Discussion on S4ME
Cohorts in this study
Phenotype:
ME/CFS
ARSD,
CDNF,
FABP5,
MT-ATP6,
MT-CO1,
MT-CO2,
MT-CO3,
MT-CYB,
MT-ND3,
MT-ND5,
MT-RNR1,
MT-RNR2,
NEXN,
PIP4K2A,
RPS26,
S100B,
SAT1,
SWI5,
TLK1,
TRAPPC5,
TRIM58,
UBE2E3,
UBXN11,
VCL
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Notes
- Consistent genes between datasets from section 2.1
- Significant genes from reanalysis of Vu et al. from Section 2.2/Supplementary File S2