Transcriptional reprogramming primes CD8+ T cells toward exhaustion in Myalgic encephalomyelitis/chronic fatigue syndrome

Authors: Iu, David S.; Maya, Jessica; Vu, Luyen T.; Fogarty, Elizabeth A.; McNairn, Adrian J.; Ahmed, Faraz; Franconi, Carl J.; Munn, Paul R.; Grenier, Jennifer K.; Hanson, Maureen R.; Grimson, Andrew

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Phenotype: ME/CFS, ME/CFS - Canadian Consensus Criteria (CCC) 2003, ME/CFS - IOM 2015, Post-exertional malaise (PEM)

ADAM19, ATP5MC1, CCL2, CCL20, CCL3, CCL3L1, CCL5, CCR4, CCR5, CD244, CD27, CD93, CLEC12A, CMKLR1, COL5A3, CSF2, CX3CR1, EOMES, EPSTI1, FCGR3A, FOS, FOSB, FOXP3, GNLY, GZMB, H3-5, HK1, HNF1A, ID2, IFI44L, IKZF2, IL16, IL17RA, IL17RB, IL18R1, IL2, IL3, IL7R, IRF1, IRF7, ITGB1, JUNB, KLRB1, KLRC4, KLRF1, LGALS1, MT-ND3, NET1, NFKB1, NFKB2, PON2, PPP2R3A, PRKCA, PTGDR, REL, RELA, RELB, RHOB, RORA, RORB, RORC, RPS26, S100B, SCGB3A1, SLAMF6, SLAMF7, SLC2A1, SUSD4, TBX21, TCF4, TCF7L2, TGFB1, THNSL2, TNFRSF1A, TOX, TPPP

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Notes

Based on genes of interest described throughout text and in figures 1C, 2D, 2G, 3B.