Whole-genome sequencing of 490,640 UK Biobank participants

Authors: Carss, Keren; Halldorsson, Bjarni V.; Hou, Liping; Liu, Jimmy; Wheeler, Eleanor; Lo, Yancy; Kundu, Kousik; Huang, Zhuoyi; Lacey, Ben; Dhindsa, Ryan S.; Rajan, Diana; Randjelovic, Jelena; Marriott, Neil; Scott, Carol E.; Yavuz, Ahmet Sinan; Johnston, Ian; Howe, Trevor; Black, Mary Helen; Stefansson, Kari; Scott, Robert; Petrovski, Slavé; Li, Shuwei; Cortes, Adrian; Hu, Fengyuan; Wang, Quanli; Burren, Oliver S.; Deevi, Sri V. V.; Haefliger, Carolina; Lythgow, Kieren; Maccallum, Peter H.; Mégy, Karyn; Mitchell, Jonathan; O’Dell, Sean; O’Neill, Amanda; Smith, Katherine R.; Taiy, Haeyam; Pangalos, Menelas; March, Ruth; Wasilewski, Sebastian; Eggertsson, Hannes P.; Moore, Kristjan H. S.; Hauswedell, Hannes; Eiriksson, Ogmundur; Skaftason, Aron; Gislason, Nokkvi; Sigurjonsdottir, Svanhvit; Ulfarsson, Magnus O.; Palsson, Gunnar; Hardarson, Marteinn T.; Oddsson, Asmundur; Jensson, Brynjar O.; Kristmundsdottir, Snaedis; Sigurpalsdottir, Brynja D.; Stefansson, Olafur A.; Beyter, Doruk; Holley, Guillaume; Tragante, Vinicius; Gylfason, Arnaldur; Olason, Pall I.; Zink, Florian; Asgeirsdottir, Margret; Sverrisson, Sverrir T.; Sigurdsson, Brynjar; Gudjonsson, Sigurjon A.; Sigurdsson, Gunnar T.; Halldorsson, Gisli H.; Sveinbjornsson, Gardar; Styrkarsdottir, Unnur; Magnusdottir, Droplaug N.; Snorradottir, Steinunn; Kristinsson, Kari; Sobech, Emilia; Thorleifsson, Gudmar; Jonsson, Frosti; Melsted, Pall; Jonsdottir, Ingileif; Rafnar, Thorunn; Holm, Hilma; Stefansson, Hreinn; Saemundsdottir, Jona; Gudbjartsson, Daniel F.; Magnusson, Olafur T.; Masson, Gisli; Thorsteinsdottir, Unnur; Helgason, Agnar; Jonsson, Hakon; Sulem, Patrick; Sandhuria, Jatin; Richardson, Tom G.; Howe, Laurence; Robins, Chloe; Liu, Dongjing; Albers, Patrick; Pereira, Mariana; Seaton, Daniel; Aulchenko, Yury; Whittaker, John; Dermitzakis, Manolis; Johnson, Toby; Davitte, Jonathan; Ingelsson, Erik; Molineros, Julio; Zhang, Yanfei; Li, Alexander H.; Baugh, Evan H.; Mlynarski, Elisabeth; Torshizi, Abolfazl Doostparast; Abdel-Azim, Gamal; Mautz, Brian; He, Karen Y.; Xi, Jingyue; Nieves-Rodriguez, Shirley; Khan, Asif; Xu, Songjun; Liu, Xingjun; Sarver, Brice; Truong, Dongnhu; Temanni, Mohamed-Ramzi; Whelan, Christopher D.; Goretti, Letizia; Khan, Najat; Fraile, Belen; Mansi, Tommaso; Rajagopal, Guna; Akhtar, Shaheen; Austin-Guest, Siobhan; Barber, Robert; Barrett, Daniel; Bellerby, Tristram; Clarke, Adrian; Clark, Richard; Coppola, Maria; Cornwell, Linda; Crackett, Abby; Dawson, Joseph; Day, Callum; Dove, Alexander; Durham, Jillian; Fairweather, Robert; Ferrero, Marcella; Fenton, Michael; Fordham, Howerd; Fraser, Audrey; Heath, Paul; Heron, Emily; Hornett, Gary; Hughes-Hallett, Lena; Jackson, David K.; Jakubowski Smith, Alexander; Laverack, Adam; Law, Katharine; Leonard, Steven R.; Lewis, Kevin; Liddle, Jennifer; Lindsell, Alice; Linsdell, Sally; Lovell, Jamie; Mack, James; Mallalieu, Henry; Mamun, Irfaan; Monteiro, Ana; Morrow, Leanne; Pardubska, Barbora; Popov, Alexandru; Sloper, Lisa; Squares, Jan; Still, Ian; Taylor, Oprah; Taylor, Sam; Tovar Corona, Jaime M.; Trigg, Elliott; Vancollie, Valerie; Voak, Paul; Weldon, Danni; Wells, Alan; Wells, Eloise; Williams, Mia; Wright, Sean; Miletic, Nevena; Lenhardt Ackovic, Lea; Slavkovic-Ilic, Marijeta; Lazarevic, Mladen; Aigrain, Louise; Redshaw, Nicholas; Quail, Michael; Shirley, Lesley; Thurston, Scott; Ellis, Peter; Grout, Laura; Smerdon, Natalie; Gray, Emma; Rance, Richard; Langford, Cordelia; Collins, Rory; Effingham, Mark; Allen, Naomi; Sellors, Jonathan; Sheard, Simon; Pancholi, Mahesh; Clark, Caroline; Burkitt-Gray, Lucy; Welsh, Samantha; Fry, Daniel; Watson, Rachel; Carson, Lauren; Young, Alan; Mehio, Rami; Schulz-Trieglaff, Ole

Nature, 6 Aug 2025

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Cohorts in this study

Phenotype: ME/CFS

ABCC5, ACOT6, ANO10, BTN2A1, C1QTNF7, CTAG2, DOK3, DPP3, JARID2, KMT5B, MLLT1, MYL6, OCSTAMP, RAB40A, SLC18A2, SPATA16, SPATA25, TRPM3, UIMC1, WWC1

Search for these genes


Notes

20 most significant genes for "120010#Ever had chronic Fatigue Syndrome or Myalgic Encephalomyelitis (M.E.)" trait from azphewas.com. (All ancestries and all gene collapsing models, except the negative control synonymous model.)